{"id":1290165,"date":"2025-01-30T09:19:29","date_gmt":"2025-01-30T03:49:29","guid":{"rendered":"https:\/\/trak.in\/stories\/?p=1290165"},"modified":"2025-01-30T09:20:03","modified_gmt":"2025-01-30T03:50:03","slug":"cancer-cells-tricked-to-destroy-themselves-by-genetic-editing","status":"publish","type":"post","link":"https:\/\/trak.in\/stories\/cancer-cells-tricked-to-destroy-themselves-by-genetic-editing\/","title":{"rendered":"Cancer Cells Tricked To Destroy Themselves By Genetic Editing"},"content":{"rendered":"\n<p>Cancer still eludes treatment, and tumors frequently evolve resistance mechanisms to get around medications.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"617\" src=\"https:\/\/trak.in\/stories\/wp-content\/uploads\/2025\/01\/Screenshot-2025-01-30-at-9.15.21\u202fAM-1024x617.png\" alt=\"Cancer Cells Tricked To Destroy Themselves By Genetic Editing\" class=\"wp-image-1290174\" srcset=\"https:\/\/trak.in\/stories\/wp-content\/uploads\/2025\/01\/Screenshot-2025-01-30-at-9.15.21\u202fAM-1024x617.png 1024w, https:\/\/trak.in\/stories\/wp-content\/uploads\/2025\/01\/Screenshot-2025-01-30-at-9.15.21\u202fAM-300x181.png 300w, https:\/\/trak.in\/stories\/wp-content\/uploads\/2025\/01\/Screenshot-2025-01-30-at-9.15.21\u202fAM-768x463.png 768w, https:\/\/trak.in\/stories\/wp-content\/uploads\/2025\/01\/Screenshot-2025-01-30-at-9.15.21\u202fAM-1536x926.png 1536w, https:\/\/trak.in\/stories\/wp-content\/uploads\/2025\/01\/Screenshot-2025-01-30-at-9.15.21\u202fAM.png 1632w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>By making cancer cells suicidal and turning them against one another, scientists have created a novel way to fight cancer.<\/p>\n\n\n\n<p><strong>Cancer Cells Self-Destruction Through Genetic Editing<\/strong><\/p>\n\n\n\n<p>Two &#8220;switches&#8221; are inserted into engineered cancer cells using this method:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>When exposed to a particular drug, the first switch causes the altered cells to <a href=\"https:\/\/www.techspot.com\/news\/103738-scientists-trick-cancer-cells-self-destructing-through-genetic.html\">multiply and take<\/a> over the tumor population.<\/li>\n\n\n\n<li>The dominant modified cells and their unmodified neighbors are killed by a toxin released by the second switch.<\/li>\n<\/ul>\n\n\n\n<p>The &#8220;dual switch selection gene drive,&#8221; an inventive technique, was described in detail in a study that was published in Nature Biotechnology.<\/p>\n\n\n\n<p>As tumors develop resistance mechanisms, such as inactivating medications or changing specific pathways, current cancer treatments face difficulties.<\/p>\n\n\n\n<p>Although there are few effective options, particularly for cancers with unclear therapeutic targets, combination therapies are frequently used to combat resistance.<\/p>\n\n\n\n<p>The novel method adopts a different strategy by taking advantage of the tumor&#8217;s capacity for quick evolution and turning it against it.<\/p>\n\n\n\n<p><strong>Lung Cancer Cells and Medication Employed by Researchers<\/strong><\/p>\n\n\n\n<p>Researchers employed lung cancer cells and the medication erlotinib, which normally inhibits the EGFR protein to stop unchecked growth, in proof-of-concept studies.<\/p>\n\n\n\n<p>By giving lung cancer cells a &#8220;suicide gene&#8221; that counteracted the effects of erlotinib, the researchers were able to make the altered cells multiply quickly in response to the medication.<\/p>\n\n\n\n<p>The engineered cells dominated the tumor population when erlotinib was administered to a mixture of modified and unmodified cells.<\/p>\n\n\n\n<p>Once dominance was attained, the researchers stopped using erlotinib and used 5-FC, a harmless substance, to activate the second &#8220;suicide gene&#8221;.<\/p>\n\n\n\n<p>The entire tumor population was essentially eradicated by the second gene&#8217;s expression of an enzyme that changed 5-FC into the extremely toxic anti-cancer medication 5-FU.<\/p>\n\n\n\n<p>Within 20 days, the altered cells surpassed the original tumors in mice with non-small cell lung cancer.<\/p>\n\n\n\n<p>After the second gene was activated, the mice&#8217;s tumors completely regressed by day 80.<\/p>\n\n\n\n<p>To ascertain this method&#8217;s wider applicability, researchers are currently experimenting with different cancer types and medication combinations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cancer still eludes treatment, and tumors frequently evolve resistance mechanisms to get around medications. By making cancer cells suicidal and turning them against one another, scientists have created a novel way to fight cancer. Cancer Cells Self-Destruction Through Genetic Editing Two &#8220;switches&#8221; are inserted into engineered cancer cells using this method: The &#8220;dual switch selection [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":1290174,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[351],"tags":[7015,7016],"class_list":["post-1290165","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-cancer-cells","tag-genetic-engineering"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cancer Cells Tricked To Destroy Themselves By Genetic Editing - Trak.in - Indian Business of Tech, Mobile &amp; Startups<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trak.in\/stories\/cancer-cells-tricked-to-destroy-themselves-by-genetic-editing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cancer Cells Tricked To Destroy Themselves By Genetic Editing - Trak.in - Indian Business of Tech, Mobile &amp; Startups\" \/>\n<meta property=\"og:description\" content=\"Cancer still eludes treatment, and tumors frequently evolve resistance mechanisms to get around medications. By making cancer cells suicidal and turning them against one another, scientists have created a novel way to fight cancer. 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